Industry Summary Articles

Simulations Plus, Inc. today announced that it has released version 2 of its in vitro data analysis program, MembranePlus™.

John DiBella, vice president for marketing and sales for Simulations Plus, said: “For over 20 years, significant research has been devoted to in vitro permeability and hepatocyte systems, with several guidelines being published and all pharmacopeia describing appropriate methods for testing. These experiments are expensive and, quite often, pharmaceutical researchers overlook key processes when analyzing their results. The improvements in this version of MembranePlus make it easier to model companies’ data and unlock important insights from common membrane assays. This leads to improved in vitro-in vivo extrapolation (IVIVE) predictions when transferred to GastroPlus™ models, which is a hot topic in the industries we serve. Already, a number of companies are requesting evaluation licenses, and we are excited for them to recognize the value MembranePlus will provide, both by improving the efficiency of their data analysis and the accuracy of their GastroPlus simulations.”

James Mullin, Principal Scientist and MembranePlus product manager, added: “The enhancements found in MembranePlus 2 include: new mechanistic models for in vitro hepatocyte assays (sandwich and suspended); new estimation methods for key parameters to better inform GastroPlus models; enhancements to the optional ADMET Predictor™ Module; and improved output reporting for all simulation modes. We expect these program enhancements to benefit a broad range of GastroPlus customers from discovery scientists to DMPK researchers and CROs.”

To view the original press release, please click here.

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