This presentation, made at PLM Road Map Fall 2021 considers the premise that collaboration in a large, global, distributed supply chain of design and development partners is seriously hindered by both ineffective implementation of interoperability standards industry-wide, and the selective capabilities embraced by PLM providers. These two factors prevent the digital continuity needed to set up a Model-Based Enterprise. Future A&D development of civil aircraft, aerospace products, and associated systems will rely on model-based paradigms. In addition, a Model-Based Enterprise (MBE) will require long-term archiving and retrieval of the associated model-based design, more specialized and complex data structures, and management of their meta data. Globally, PLM interoperability standards and associated Interoperability Forums are identified as key enablers to support the new ways of working, based on the introduction of digital twins that will exist in a digital ecosystem. This presentation reports on work by the A&D PLM Action Group which has come together to examine the value proposition of standards enablement of MBE interoperability. The report begins by framing the problem, followed by articulation of objectives, requirements, and desired future state. The discussion then progresses to recommendation of a first set of interoperability standards for key MBE focus areas, including Model-Based Definition, Multi-View Bill of Materials, Global Collaboration and Model-Based Systems Engineering, and concludes with a plan for accelerating adoption.